Forty-two new weekly flight to a host of destinations are now taking off from Robin Hood airport.
Eight new routes to Paris, Amsterdam, Berlin, Jersey, Newquay, Malaga, Alicante and Faro are scheduled as part of a Flybe deal with the Doncaster Sheffield Airport.
The airline will also operate a business route to Dusseldorf from Thursday (March 31).
The first flight to Paris set off on board an Embraer 195 jet emblazoned with eye-catching Welcome to Yorkshire livery.
The aircraft will promote the region to potential tourists across Europe and the UK, as part of a deal which saw Doncaster Sheffield Airport and Flybe announced as the official airport and airline partner of the tourism agency respectively.
Flybe will deliver the largest number of departures from the airport, just down the M180, offering 42 extra flights a week.
Steve Gill, managing director of Doncaster Sheffield Airport, was delighted to see the first Flybe flight taking passengers to Paris.
